Colchicine















































If co-administration of Colchicine pills as well as a P-gp inhibitor is essential, the dose of Colchicine pills need to be changed by either reducing the everyday dose or lessening the dose regularity, and also the patient must be checked very carefully for Colchicine poisoning [View Clinical Pharmacology (12)]



Some drugs such as HMG-CoA reductase inhibitors and fibrates might raise the risk of myopathy when combined with Colchicine pills. Grievances of muscle discomfort or weak point can be a sign to check serum creatinine kinase levels for indicators of myopathy.



4 pharmacokinetic researches examined the effects of co-administration of voriconazole (200 milligrams BID), fluconazole (200 mg QD), cimetidine (800 mg BID), as well as propafenone (225 mg BID) on wide spread levels of Colchicine. Colchicine could be administered with these drugs at the checked doses without a requirement for dosage modification. However, these outcomes need to not be extrapolated to various other co-administered medications [ See Drug-Drug Interactions (7.1, 7.2) and also Pharmacokinetics (12.



Pregnancy Category C. There are no well-controlled and appropriate studies with Colchicine pills in expecting females. Colchicine goes across the human placenta. Developmental researches in animals were not carried out with Colchicine capsules, nevertheless posted pet reproduction and advancement researches with Colchicine showed embryofetal poisoning, teratogenicity, as well as modified postnatal development at exposures within or over the scientific restorative variety. If the potential perk validates the potential threat to the fetus, Colchicine must be used throughout pregnancy simply.

Colchicine